PFAS are per- and polyfluoroalkyl substances that are used in clothing, fire retardants, non-stick applications etc. and extremely difficult to destroy and have adverse health effects. Fraunhofer USA Center for Coatings and Diamond Technologies (Fraunhofer USA CCD) are investigating electrochemical oxidation (EO) with boron-doped diamond (BDD) electrodes. The destructive nature of the technology lends itself to applicability in complex media such as IX regenerates, RO rejects, Aqueous film forming foam (AFFF), industrial wastewaters, and landfill leachates, among others. Whether as a primary treatment option for complex samples or a secondary treatment option for large-scale remediation, EO with BDD electrodes has shown considerable promise for permanent destruction of PFAS compounds.